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Multi-residue method for the determination of antibiotics and some of their metabolites in seafood

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dc.contributor.author Serra Compte, Albert
dc.contributor.author Álvarez-Muñoz, Diana
dc.contributor.author Rodríguez Mozaz, Sara
dc.contributor.author Barceló i Cullerés, Damià
dc.date.issued 2017-06-01
dc.identifier.issn 0278-6915
dc.identifier.uri http://hdl.handle.net/10256/14366
dc.description El títol de la versió postprint d'aquest article és: 'Fast methodology for the determination of a broad set of antibiotics and some of their metabolites in seafood'
dc.description.abstract The presence of antibiotics in seafood for human consumption may pose a risk for consumers. A methodology for the analysis of antibiotics in seafood based on QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction, followed by detection and quantification using liquid chromatography coupled to mass spectrometry was developed. The analytical method was evaluated for the determination of 23 antibiotics (including parent compounds and some metabolites) in fish, mussels and clams. Recoveries ranged between 30% and 70% for most of the compounds and method detection and quantification limits (MDLs and MQLs) were between 0.01 and 0.31 ng/g dry weigh (dw) and 0.02–1.03 ng/g (dw) respectively. Real seafood samples were analysed using this method. Nine antibiotics were found at levels above MDLs; however none of them exceed the maximum residue limits (MRL) established by the authorities. Tetracycline was the most ubiquitous compound, presenting also the highest concentration: 5.63 ng/g (dw) in fish from Netherlands. In addition, an alternative technique based on microbial growth inhibition was explored as semiquantitative detection method of antibiotics in seafood. This methodology c ould be applied as a fast screening technique for the detection of macrolides and β-lactams in seafood but further research is needed for other antibiotics families cat
dc.description.sponsorship The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under the ECsafeSEAFOOD project (grant agreement n° 311820) and the SEA-on-a-CHIP project (grant agreement no. 614168). It has been co-financed by the European Union through the European Regional Development Fund (ERDF). This work has also been partly funded by the Generalitat de Catalunya (Consolidated Research Groups 2014-SGR-291-Catalan Institute for Water Research 2014 & 2014-SGR-418-Water and Soil Quality Unit) cat
dc.format.mimetype application/pdf cat
dc.language.iso eng cat
dc.publisher Elsevier cat
dc.relation.isformatof Versió postprint del document publicat a: https://doi.org/10.1016/j.fct.2016.11.031 cat
dc.relation.ispartof © Food and Chemical Toxicology, 2017, vol. 104, p. 3-13 cat
dc.relation.ispartofseries Articles publicats (ICRA) cat
dc.rights Tots els drets reservats cat
dc.subject Antibiòtics cat
dc.subject Antibiotics cat
dc.subject Cromatografia de líquids cat
dc.subject Liquid chromatography cat
dc.subject Espectrometria de masses cat
dc.subject Mass spectrometry cat
dc.subject Contaminants emergents en l'aigua cat
dc.subject Emerging contaminants in water cat
dc.subject Toxicologia ambiental cat
dc.subject Environmental toxicology cat
dc.subject Marisc -- Toxicologia cat
dc.subject Seafood -- Toxicology cat
dc.title Multi-residue method for the determination of antibiotics and some of their metabolites in seafood cat
dc.type info:eu-repo/semantics/article cat
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess cat
dc.embargo.lift 2018-09-07T07:24:24Z
dc.embargo.terms 12 mesos cat
dc.date.embargoEndDate info:eu-repo/date/embargoEnd/2018-06-01 cat
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/311820 cat
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/614168 cat
dc.type.version info:eu-repo/semantics/acceptedVersion cat
dc.identifier.doi https://doi.org/10.1016/j.fct.2016.11.031

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